CRISPR-CAS9 APPLICATIONS IN FUNCTIONAL GENOMICS AND GENE THERAPY

Authors

  • Hina Baig Department of Life Sciences, University of Karachi, Pakistan. Author

DOI:

https://doi.org/10.71465/hjmri.254

Keywords:

CRISPR-Cas9, Genome Editing, Functional Genomics, Gene Therapy

Abstract

Targeted manipulation of DNA with unprecedented precision, efficiency, and versatility. Its impact spans functional genomics—enabling gene knockout, activation, and repression screens—to transformative applications in gene therapy, including the correction of genetic mutations in inherited disorders. This paper explores the molecular mechanism of CRISPR-Cas9, its applications in functional genomic analysis, its therapeutic relevance, challenges in delivery systems, and ethical implications. It also highlights the contributions of Pakistani research institutions in this growing domain and outlines future directions for clinical translation.

image

Downloads

Published

2024-08-10

Issue

Vol. 4 No. 8 (2024): Holistic Journal of Multidisciplinary Research Innovation

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

All articles published in the Holistic Journal of Multidisciplinary Research Innovation are licensed under an open access model. Authors retain copyright of their work and grant the journal the right of first publication. The content may be freely used, distributed, and reproduced in any medium, provided the original work is properly cited and remains unaltered.