MOLECULAR SIGNALING PATHWAYS IN CANCER METASTASIS

Authors

  • Muhammad Zubair Center for Cancer Research, Aga Khan University, Karachi, Pakistan Author

DOI:

https://doi.org/10.71465/hjmri.266

Keywords:

Cancer metastasis, signaling pathways, epithelial-to-mesenchymal transition, molecular oncology

Abstract

 

 

                 Cancer metastasis remains the most lethal aspect of tumor progression, responsible for over 90% of cancer-related deaths. This article investigates the critical molecular signaling pathways that drive metastasis, including PI3K/AKT, MAPK/ERK, TGF-β, Wnt/β-catenin, and NF-κB. These pathways regulate epithelial-to-mesenchymal transition (EMT), angiogenesis, immune evasion, and extracellular matrix remodeling. Understanding these interconnected networks offers therapeutic potential in halting the metastatic cascade. This article presents an in-depth analysis of their roles, cross-talk, clinical relevance, and prospects for targeted interventions in Pakistani oncology research.

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Published

2024-10-10

Issue

Vol. 4 No. 10 (2024): Holistic Journal of Multidisciplinary Research Innovation

Section

Articles

License

Creative Commons License

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