NEUROGENESIS AND SYNAPTIC PLASTICITY IN ADULT MAMMALIAN BRAINS

Abstract

Neurogenesis and synaptic plasticity are critical processes for learning, memory, and repair in adult mammalian brains. Contrary to previous assumptions, adult neurogenesis occurs in specific regions such as the hippocampus and subventricular zone. Synaptic plasticity, the brain’s ability to adapt and strengthen connections between neurons, complements neurogenesis in supporting cognitive function and recovery from neural injury. This article examines molecular regulators, cellular mechanisms, regional specificity, and translational perspectives of adult neurogenesis and synaptic plasticity, with a focus on their implications in neurodegenerative disorders. Current findings from Pakistani research institutions and emerging therapeutic prospects are discussed.